anti-inflammatory effect of the epigallocatechin gallate following spinal cord trauma in rat

نویسندگان

علیرضا خلعتبری

ali reza khalatbary حسن احمدوند

hassan ahmadvand

چکیده

background: spinal cord injury (sci) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. the purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (egcg) on traumatized spinal cord. methods: rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group, and egcg-treatment groups (50 mg/kg, i.p., immediately and 1 hour after sci). spinal cord samples were taken 24 hours after injury and studied for determination of myeloperoxidase (mpo) activity, histopathological assessment and immunohistochemistry of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), nitrotyrosine, inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and poly(adp-ribose) polymerase (parp). results: the results showed that mpo activity was significantly decreased in egcg-treatment groups. attenuated tnf-α, il-1β, nitrotyrosine, inos, cox-2, and parp expression could be detected in the egcg treated rats. also, egcg attenuated myelin degradation. conclusion: on the basis of these findings, we propose that egcg may be effective in protecting rat spinal cord from secondary damage by modulating the inflammatory reactions.

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Anti-Inflammatory Effect of the Epigallocatechin Gallate Following Spinal Cord Trauma in Rat

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عنوان ژورنال:
iranian biomedical journal

جلد ۱۵، شماره ۱، صفحات ۳۱-۳۷

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